The Center for Inherited Disease Research (CIDR)'s  mission is to support the genetics community by providing high-quality, cutting-edge genomics services and technologies in order to expand our understanding of disease and catalyze discoveries that translate to patient care.  All NIH CIDR Program studies are supported by data sharing assistance. GWAS and sequencing studies are additionally provided both data cleaning services. GWAS studies include imputation services.Established TechnologiesSNP Genotyping, Using Illumina Infinium chemistries and Affymetrix Axiom chemistry, investigators hav… [learn more]

The Chemistry and Synthesis Center (CSC) of the National Heart, Lung, and Blood Institute (NHLBI) provides IRP scientists with targeted imaging probes and chemical tools that help accelerate cell-based assays, in vivo imaging studies, and translational research leading to better disease diagnosis and therapy. It comprises a core synthesis facility dedicated to the preparation of imaging probes, including radiolabeling for PET and SPECT applications, and a research component dedicated to the discovery of new imaging approaches and compositions. Established Tec… [learn more]

The Mid-Atlantic CHTN is one of six participating divisions of the Cooperative Human Tissue Network (CHTN) and is based in the Pathology Department at the University of Virginia. While primarily a resource for cancer researchers, samples provided by the CHTN support projects in many biomedical and basic science fields. In addition to tissue and biofluid specimens, the Mid-Atlantic Division specializes in the construction and distribution of tissue microarrays (TMAs). TMAs allow immunohistochemical and colorimetric staining for biomarkers on many samples in paralle… [learn more]

The CHTN is a unique NCI-supported resource that provides human tissues and fluids from routine procedures to investigators who utilize human biospecimens in their research. Unlike tissue banks, the CHTN works prospectively with each investigator to tailor specimen acquisition and processing to meet their specific project requirements. High quality biospecimens are available from surgeries, autopsies and other routine procedures. Types of preservation methods available include fresh, frozen, floating fixative, RNAlater, and paraffin embedded. The CHTN is NCI subsidized allowing for below marke… [learn more]

DTP’s Natural Products Repository is the world’s largest storehouse of natural products. It houses close to >200,000 extracts from samples of more than 70,000 plants and >20,000 marine organisms collected from more than 29 countries, plus extracts of diverse bacteria and fungi. In addition, the NCI Natural Products Repository also includes pre-fractionated natural products extracts created through the NCI Program for Natural Products Discovery. The pre-fractionated extract library has 500,000 partially-purified plated fractions, created from NPB crude extracts, available for screening. The… [learn more]

We have compiled an NIH-wide database of cold storage units for use in case of unexpected failures. The database includes 4°C, -20°C, -80°C, and LN2 storage units belonging to NIH researchers who have kindly agreed to temporarily share their units with other NIH researchers. The database can be accessed here: NIH-Wide Cold Storage Database. [learn more]

The Molecular Pathology Unit is intended to spearhead opportunities for bridging basic and clinical research efforts by more precisely optimizing the development, characterization and utilization of models of human disease. The initiative approach includes both applied research and collaborations aimed at developing new reagents, methods, and technologies in preclinical diagnostic medicine; thus enhancing capabilities to integrate molecular and systemic aspects of disease mechanisms. Designing and employing state of the art medical and pathology investigative tools to the study of animal model… [learn more]

The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA screens, informatics/pathway analysis and rigorous follow-up. Genome-wide siRNA screens for human and mice are available. Also routinely included in screens are miRNA mimic and inhibitor libraries. Resources: Screening Libraries Ambion Silencer Select Human Genome-Wide siRNA library targeting ~22,000 genes with th… [learn more]

The Specimen Resource Locator (SRL) is a biospecimen resource database designed to help researchers locate resources that may have the samples needed for their investigational use. This publicly searchable database includes information about biospecimen banks and sample procurement services. The specimens and samples come from non-commercial, either NCI or non-NCI-funded resources. Investigators can search the database and gain access to thousands of specimens of various tumor, organ, and preservation methods. Please submit all SRL inquiries using the “Contact the Expediter” button on t… [learn more]

The NHLBI Transgenic Core’s main mission is to keep up with the latest advancements in genome engineering technologies and to provide state-of-the-art services to assist NIH scientists in generating genetically engineered animal models. In the past several years, the Core has successfully used the ZFN, TALEN, and CRISPR methods to generate gene-targeted mouse lines. The revolutionary CRISPR technology has enabled the Core to simultaneously target multiple genomic loci and achieve gene knockout in difficult mouse strains, such as immunocompromised mice. Besides developing these new techn… [learn more]

The NIA Nonhuman Primate (NHP) Core Facility maintains a colony of rhesus macaques at the National Institutes of Health Animal Center. Established in 2012, the Core's mission is to offer research services supporting multi-disciplinary translational aging projects.  Working with investigators, we develop experimental protocols to evaluate various aspects of NHP aging.  We provide all supportive care for the research animals, complete all regulatory requirements,  conduct in vivo experiments, and collect and organize study data.  The NIA IRP's 30 years of NHP research experience has made us… [learn more]

The facilities at AIM are available for use by the entire NIH intramural research community. While we welcome users with any size imaging project, AIM specializes in large, yearlong (or longer), collaborative research efforts with NIH labs – providing sample preparation, microscope operation and development, and data processing/analysis as needed. We take care of the imaging and processing so that you can focus on the biology. Established Technologies: Microscope Description Spatial Res… [learn more]

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement, and analysis. BEPS is centrally located on the main NIH campus and provides expertise that spans technologies ranging in scale from near-atomic resolution to intact organisms. Established Technologies: Electron Microscopy The Electron Microscopy Unit provides instrumentation, training, and services for: immuno electron microscopy, electron tomography, and specimen preparation, including cryo-techniq… [learn more]

Description: The NIDDK Central Repository (NIDDK-CR) provides controlled access to data and sample Resources for Research (R4R) from extramurally funded studies available to the research community for the advancement of NIDDK mission. The Repository provides a centralized location to evaluate resources available, customize sample selection criteria to fit researchers’ needs, and a mechanisms to apply for access and for reporting back to the community on the utilization of the resources. Contact Information: For questions or comments about the NIDDK Central Repository, or to contact someon… [learn more]

The mission of the Human Energy and Body Weight Regulation Core is to collaborate with investigators from across the NIDDK, clinical research programs at the NIH, and other institutions by performing metabolic and physiological phenotyping measurements in healthy volunteers as they relate to obesity, physical activity, and energy metabolism, and in patients with metabolic disorders as they relate to specific metabolic dysregulations. Established Technologies: The Core supports the collection of highly sensitive, continuous measurements of whole-body energy metabolism. We use standa… [learn more]

The NIH Biowulf Cluster provides researchers with a world-class system to assist in solving complex biomedical problems as diverse as gene variation in worldwide human populations, deep learning to model protein structures, and PET brain scan processing to identify plaques associated with Alzheimer’s disease. The Biowulf cluster requires an HPC account and a justification describing the computational requirements of the proposed research project. Customer Benefits: The Biowulf cluster comprises over 105,000 cores communicating over dedicated high-speed networks and utilizing shared file… [learn more]

The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is a trans-NIH resource whose mission is to provide a collaborative hub of advanced translational immunology for NIH clinical and pre-clinical studies. This uniquely structured program provides centralized and efficient management of projects in full collaboration with NIH investigators to better understand human immune function and pathophysiology. Our team works closely to plan and optimize experimental workflows tailored to each investigator’s specific research goals; execute highly sophisticated t… [learn more]

The Clinical Image Processing Service (CIPS) offers timely and accurate advanced image processing of diagnostic radiology images for clinical care, research, and training. CIPS’ functions include clinical services and scientific researches. Established Technologies: CIPS can process most modern imaging modalities such as MR, CT, PET and Ultrasound in anatomical regions from the hand to the heart. The CIPS lab currently offers services in seven exam categories: IP Dynamic Enhancement Dynamic Enhancement MRI (DEMRI) is a type of MRI study in which intravenous contrast is administered… [learn more]

The Department of Laboratory Medicine provides state-of-the-art laboratory testing in support of Clinical Center patient care and will serve as a center of excellence in research and training in laboratory medicine, particularly in areas which utilize the unique strengths of the National Institutes of Health. Goals We are committed to the following goals:, Respectful, compassionate, and high-quality patient care, High standards of clinical laboratory practice and efficiency, Optimal support of clinical research protocols, Excellence in applied and medi… [learn more]

Radiology and Imaging Sciences provides imaging services for National Institutes of Health (NIH) Clinical Center patients participating in research protocols conducted by the various NIH institutes. Services include X-rays, fluoroscopy, ultrasound, magnetic resonance imaging (MRI) scans, computed tomography (CT) scans, and interventional radiology (special procedures).Radiology also conducts research studies of clinical imaging procedures and offers training in biomedical imaging research.Established Technologies Radiology Body Imaging (conventional x… [learn more]

The Metabolic Clinical Research Unit (MCRU) opened in 2007 as a key component of the Strategic Plan for NIH Obesity Research . The NIDDK worked closely with the Clinical Center to design the Unit, which houses state-of-the-art facilities and equipment for a wide range of metabolic clinical research studies. The MCRU brings together experts in a wide range of fields including metabolism, endocrinology, nutrition, cardiovascular biology, gastroenterology, hepatology, genetics, and behavioral sciences. It supports protocols designed by researchers from across all NIH institutes investigating the … [learn more]

The Neurorehabilitation and Biomechanics Research Section (also referred to as the NAB LAB) is a multidisciplinary group of highly qualified scientists, clinical and technical staff, and trainees with diverse backgrounds including medical, physical therapy, neuroscience and biomedical engineering expertise. Clinical Services Clinical services include comprehensive physical and functional assessments by Certified Adult and Pediatric Physical Medicine and Rehabilitation Medicine physicians and our team of physical therapists. Based on this initial assessment additional evaluations may be rec… [learn more]

The NIH Clinical Center Pharmacy Department provides pharmaceutical care to inpatients and outpatients on NIH intramural research protocols at the NIH Clinical Center. The Clinical Center facility encompasses 200 inpatient beds, 93 day-hospital stations, and 15 clinics. Clinical Center pharmacy staff provide sophisticated research support to health care providers as well as clinical investigators. Pharmacists conduct and participate in research programs that enhance knowledge regarding investigational drugs and new uses of commercially available agents. The Pharmacy Department's Investigation… [learn more]

The PET Department, CC, functions as a core facility that supports basic, translational, and clinical research using PET. It is a vertically integrated facility, with resources to produce positron-emitting radionuclides, manufacture PET radiopharmaceuticals in a cGMP facility, and use them to image CC patients. Our staff includes cyclotron engineers, radiochemists, physicians, physicists, radiopharmacists, imaging technologists, and regulatory/quality assurance experts. Resources include: Two GE PETtrace cyclotrons on the B3 level of Bldg 10, installed in 20… [learn more]

The Center of Cellular Engineering (CCE) is a comprehensive facility that develops and manufactures a wide range of cell and gene therapies for early phase clinical trials. The CCE is currently manufacturing chimeric antigen receptor (CAR) T-cells, T-cell receptor (TCR)-engineered T-cells, cancer vaccines, induced pluripotent stem cells (iPSC), retinal pigmented epithelial cells derived from autologous iPSC and genetically modified hematopoietic stems cells. In the past the CCE has manufactured dendritic cells, NK cells, virus specific T-cells and mesenchymal stromal cells. The CCE also proces… [learn more]

The Common Fund Glycoscience Program supports the development and dissemination of straightforward and accessible resources, including methods, technologies, and reagents, to study the structure and function of carbohydrates in biomedically relevant systems. Resources developed in the program are intended to be easily and broadly adopted by the research community outside the area of glycoscience, facilitating the integration of glycoscience with other scientific disciplines. Specific goals of the program include the development of resources for: improved carbohydrate synthesis; analytical tool… [learn more]

NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and infectious pathogens, using single particle or cryo-tomography approaches. Fine detailed 3D maps computed by electron micrographs spark numerous biological insights in cancer research, infectious disease research, vaccine design, cell development, and human physiological and functional stud… [learn more]

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to bring genomic sequence to biology and medicine. We accomplish this by meeting with each NIH investigator to discuss the details of their project to determine which method(s) would work best. The most common types of sequencing projects include whole exome sequencing, RNA sequencing, custom capture sequencing, CHiP-seq, and whole genome sequencing. However, we are always inte… [learn more]

The Mouse Imaging Facility (MIF) is a shared, trans-NIH intramural resource for animal imaging studies. MIF provides access to state-of-the-art radiological imaging methods optimized for mice, rats, other animals, and tissue samples. MIF provides intellectual, technical, and material support for investigators using the MIF imaging facilities. The MIF is supported by all institutes at the NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, the MIF resides within NINDS and is physically located in the NIH MRI Research Center (NMRC) … [learn more]

The NIH MRI Research Facility (NMRF) is a shared, intramural resource for human imaging studies. The NMRF is supported by all Institutes at NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, NMRF resides within NINDS. The NMR Center Steering Committee provides the direct oversight for NMRF activities. Service Offerings Provide intellectual, technical and material support for investigators using its imaging and computer resources. , MRI using a state-of-the-art 7.0 T human MRI system and other resour… [learn more]

With specimens that span neurological, neuropsychiatric, and neurodevelopmental diseases and disorders, the NBB serves as a central point of access to the world-class collections of our six biorepositories. In addition, the NBB provides researchers with a wealth of resources to facilitate their research, including medical records and clinical data sets (when available) as well as access to quality metrics and best practices used by each site. Established Technologies The NIH NeuroBioBank contains an inventory of specimens that are available through its b… [learn more]

The heart of the National Institutes of Health’s (NIH) memory is preserved within the documents and artifacts produced by the institution. The mission of the Office of NIH History and Stetten Museum (ONHM) is to document the present and the past of the NIH and to produce materials that explain the NIH’s history to the public. The Office of NIH History has both an archives and a museum. The archives is interested in unpublished documentation including laboratory notebooks; professional and personal correspondence; diaries; successive drafts of publications; course mat… [learn more]

The NIH Library is a biomedical research library, whose collection and services are available at no cost to NIH staff: Electronic Resources: Over 20,000 electronic journals, 190,000 eBooks, and 50 databases. , Training classes covering topics such as bioinformatics, systematic reviews, writing and publishing, and more. , Services NIH Library services are supported by expert librarians and information specialists at no cost to NIH staff: , 3D Printing (digital modeling and printing), Bibliometrics (customiz… [learn more]

In support of Intramural Research Program (IRP) scientists, DOHS provides training, consulting, and resources to ensure that laboratory equipment is used and maintained properly and safely. We provide expert safety and health consulting support for a variety of safety equipment and personal protective equipment (PPE). The primary means of laboratory safety include good laboratory practices and the use of containment equipment within the laboratory. Safety equipment includes biological safety cabinets (BSCs), chemical fume hoods (CFHs), PPE, and other controls designed to remove or mi… [learn more]

In support of Intramural Research Program (IRP) scientists, DOHS provides training, consulting, and resources to ensure that workers' risk to hazards and stresses in the laboratory environment is minimized. Our services include one-on-one consultation with your IC Safety and Health Specialist, ergonomic assessments, pest management, risk assessments, and safety training. Our diverse services combined with our consulting capacity and innovative tools and approach give you the support to achieve a safe and healthful working environment. Services Biological safety comp… [learn more]

The Division of Veterinary Resources’ (DVR) mission is to contribute to the advancement of NIH biomedical research programs by providing excellence in animal care, customer service, and specialized research services to support intramural research efforts. DVR’s diverse and dedicated staff emphasizes accountability to the NIH researcher’s needs in areas including humane animal and veterinary care, animal behavior and enrichment, diagnostics and health surveillance, surgery, pharmacy, procurement, nutrition, and animal transportation. Established Technologies DVR professional staff… [learn more]

The Division of Veterinary Resources Animal Surgery has supported large animal research and clinical care for more than 40 years. DVR surgeons provide outstanding and highly specialized large animal (rabbits, ungulates, etc.) research support in a state-of-the-art surgical suite. Specialty support includes surgical expertise, surgical and technical support, animal model development, and investigator training. We seek to support the unique needs and requirements of each investigator using animals in either basic or translational research. Established Technologies Facilities … [learn more]

The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, mortality, or unexpected findings. In addition, mouse phenotyping and transmission electron microscopy services are available. Established Technologies The Pathology Service offers a Mouse Phenotyping Service with comprehensive pathologic analysis for genetically engineered mice. The Service provides standardized gro… [learn more]

The National Institutes of Health (NIH) Office of Research Services (ORS) Division of Radiation Safety (DRS) Radioactive Materials Control and Analysis Branch supports radioactive materials packaging/shipping. Established Technologies In accordance with Department of Transportation (DOT) requirements, all shipments of radioactive material including biological specimens must be packaged by an individual trained in DOT Hazmat requirements before they are offered for transport on public roads. DRS maintains a roster of DOT-trained individuals who can perfo… [learn more]

MAB provides visual communication solutions across all media to the entire NIH community. Our Medical Illustration section provides a complete range of biomedical visualization services, including manuscript/textbook figures, infographics, 3D modeling, animation, technical diagrams, and journal covers. MAB also offers a complete range of graphic design and production services. We are always here to help you with your scientific poster design and printing needs, including printing on cloth. List of Services Graphic Design Branding, Campaigns, … [learn more]

The Stem Cell Unit (SCU) has established a database to which hESC lines, adult stem cells and induced pluripotent stem (iPS) cells may be directly compared. These data give scientists the information they need when choosing individual cell lines for specific projects. The initial aim of the SCU is to establish standards for all aspects of the culture process, as well as quality control and monitoring of these hESC lines. By performing these assays in a single laboratory, the SCU has established a database to which additional hESC lines, adult stem cells and induced pluripotent stem (iPS) … [learn more]

The Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability (STRIDES) Initiative The STRIDES Initiative aims to help NIH and its institutes, centers, and offices (ICOs) accelerate biomedical research by reducing barriers in utilizing commercial cloud services. This initiative aims to harness the power of the cloud to accelerate biomedical discovery. NIH and NIH-funded researchers can take advantage of STRIDES benefits. These key benefits include: Professional services—Access to professional service consultations and technical support from the S… [learn more]

The Trans-NIH Metabolomics Core (TNMC) is a shared research resource that performs metabolomics analysis (and related small molecule research) for investigators at all Institutes and Centers across the NIH Intramural Research Program. The TNMC is administered at NIEHS with participating laboratories at NIEHS, NIA, and NIAID. The TNMC was established in 2023 and continues to grow in the offerings provided, expertise, and participatory labs. Established Technologies Metabolomics measures the small molecules – endogenous and exogenous �… [learn more]